Murine T lymphomas in which the cellular myc oncogene has been activated by retroviral insertion
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Murine T lymphomas in which the cellular myc oncogene has been activated by retroviral insertion.
The myc oncogene is implicated here in T lymphocyte neoplasia. Cloning revealed a retroviral insert 0.7-1.3 kb 5' to c-myc in two T lymphomas induced by Soule murine leukemia virus and in a spontaneous T lymphoma ( Tikaut ) of an AKR mouse, a strain in which leukemogenesis involves recombinant retroviruses (MCF viruses). The tumor c-myc mRNAs appear normal but their level is approximately 5-fol...
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Alteration of the cellular myc oncogene has been strongly implicated in several types of lymphoid tumors. Although its normal role remains largely unknown, cmyc seems likely to playa crucial role in the control of cellular proliferation and appears to become oncogenic when genetic alterations deregulate its expression. The gene is activated by retroviral insertion in most avian bursal lymphomas...
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ژورنال
عنوان ژورنال: Cell
سال: 1984
ISSN: 0092-8674
DOI: 10.1016/0092-8674(84)90306-4